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Eukaryotes I - 2nd ed 35 Karp 1999 Cell& Molecular...

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1 Molecular Biology Part IV: Eukaryotes 4 I. An Introduction to the Molecular Basis of Cancer
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5 Karp 1999 Cell & Molecular Biology 2 nd ed.
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6 normal human karyotype human cancer – aneuploidy Marx, J. 2002 Science
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7 Karp 1999 Cell & Molecular Biology
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10 Lewin 2000 Genes VII
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11 Lewin 2000 Genes VII
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12 Experiment by Stehelin, Bishop, & Dulbecco 1976 Figure based on Bishop, 1982 Scientific American
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13 Watson et al. 1987 Mol. Bio. of the Gene 4 th ed.
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14 Watson et al. 1987 Mol. Bio. of the Gene 4 th ed.
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15 Karp 1999 Cell & Molecular Biology 2 nd ed. oncogenes can also be activated WITHOUT VIRUSES
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16 Lewin 2000 Genes VII
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18 Karp 1999 Cell & Molecular Biology 2nd ed.
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Unformatted text preview: 2nd ed. 35 Karp 1999 Cell & Molecular Biology 2nd ed. 36 E2F: transcription factor required for cell to enter S phase RB protein binds E2F, preventing cell from entering S (and RB + E2F represses other genes) cyclin + cyclin-dependent kinase (cdk) can phosphorylate RB, causing it to release E2F, which then binds to DNA and activates S phase genes 37 recessive mutation: one functional allele produces RB, which binds E2F and holds cell in Go ----- no functional alleles --> no RB --> E2F activates S-phase 38 39 40 What are some of the mutations that occur here? 41 Karp 1999 Cell & Molecular Biology 2 nd ed. 42 Karp 1999 Cell & Molecular Biology 2nd ed. 43 McKinnell et al. 1998 The Biological Basis of Cancer...
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