Gene Regulation - GENE REGULATION Virtually every cell in...

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GENE REGULATION Virtually every cell in your body contains a complete set of genes But they are not all turned on in every tissue Each cell in your body expresses only a small subset of genes at any time During development different cells express different sets of genes in a precisely regulated fashion
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GENE REGULATION Gene regulation occurs at the level of transcription or production of mRNA A given cell transcribes only a specific set of genes and not others Insulin is made by pancreatic cells
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CENTRAL DOGMA Genetic information always goes from DNA to RNA to protein Gene regulation has been well studied in E. coli When a bacterial cell encounters a potential food source it will manufacture the enzymes necessary to metabolize that food
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Gene Regulation In addition to sugars like glucose and lactose E . coli cells also require amino acids One essential aa is tryptophan. When E. coli is swimming in tryptophan (milk & poultry) it will absorb the amino acids from the media When tryptophan is not present in the media then the cell must manufacture its’ own amino acids
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Trp Operon E. coli uses several proteins encoded by a cluster of 5 genes to manufacture the amino acid tryptophan All 5 genes are transcribed together as a unit called an operon, which produces a
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