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Giant Cell Tumor of Bone-1

Giant Cell Tumor of Bone-1 - Giant Cell Tumor of Bone...

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Giant Cell Tumor of Bone
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Overview Definition Epidemiology Hx Presentation/Exam Radiology Dx Tx Outcomes
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Definition 1 0 bone neoplasm First described Cooper 1818 Lebert microscopic description 1845 Generally benign Potential for : Recurrence Pulmonary metastasis Frank malignancy
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Epidemiology 5-10% 1 0 bone tumors 20% benign bone tumors F : M 1.5 : 1 70-80% age 20-40 Rare skeletally immature Epiphyseal Monostotic
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Incidence Ends of long bones >50% about knee High recurrence rate 1-2% benign pulm. Mets 1 0 malignant GCT <1% Rare polyostotic form <1%
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Location
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Presentation Pain x wks. – mos. Swelling Mass Pathologic # Neuro deficit (spine / sacrum) incidental
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Radiology Lytic lesion Epipyseal Eccentric or central Narrow zone transition Cortical thinning expansile No sclerotic margin
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Imaging Occ. Cortical breakthrough +/- soft tissue mass Extend to subarticular cortex Typically no host response Often large @ presentation
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Other modalities CT Integrity cortical rim MRI Assess subchondral breakthrough Bone Scan Suspect multicentri loci ie. HAND
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