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Unformatted text preview: ed Demeclocycline 600-1200mg for 4received
14days and 3 received lithium. All patients in the
demeclocycline group had improved Na to
normal vs none in the lithium group
(N Engl J Med 298:173–177;1978) V2 receptor antagonist
• Selectively blocks binding of arginine
Selectively vasopressin fro binding to V2 receptors
causing excretion of electrolyte free water.
• Approved for use in patients with
euvolemic and hypervolemic hyponatremia SALT 1 and SALT 2 trials
• 2 multicenter, randomized, double-blind,
multicenter, placebo-controlled trials to stu...
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This note was uploaded on 12/24/2011 for the course STEP 1 taught by Professor Dr.aslam during the Fall '11 term at Montgomery College.
- Fall '11