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Unformatted text preview: SIADH
Nephrology Grand Rounds
Sheena Surindran Hyponatremia
• Physiology of Aquaporin channels / ADH
• Pathophysiology of SIADH
• Therapeutic options
• V2 receptor antagonists
• First reported in 1960’s in 2 patients with
• Criteria was developed by Schwartz and
Bartter in 1967 and has remained
unchanged since then. Discovery of Aquaporin channels
• Chance discovery by Peter Agre- John
Chance Hopkins University while isolat...
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- Fall '11