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Unformatted text preview: SIADH SIADH Nephrology Grand Rounds 9/14/2010 Sheena Surindran Hyponatremia Hyponatremia • History History • Physiology of Aquaporin channels / ADH Physiology • Pathophysiology of SIADH Pathophysiology • Therapeutic options Therapeutic • V2 receptor antagonists V2 History History • First reported in 1960’s in 2 patients with First lung cancer • Criteria was developed by Schwartz and Criteria Bartter in 1967 and has remained unchanged since then. Discovery of Aquaporin channels Discovery • Chance discovery by Peter Agre- John Chance Hopkins University while isolat...
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