Guidelines APS Journal

Guidelines APS Journal - Guidelines on the investigation...

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Guidelines on the investigation and management of the APL syndrome Dr Wan Zaidah Abdullah BJH : 2000-704-15 (Revised of !991 guidelines by the Haemostasis and thrombosis task force of the BSH )
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Definition APL antibodies comprise of a family of antibodies reactive with epitopes on proteins which are themselves complexed with negatively chaarged PL. Thus many APL antibodies require B2GP I, aPL binding plasma proteins with weak anticoagulant activity. (read on the mechanism)
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APS-definition Arterial or venous thrombosis Rec miscarriages In whom the blood tests for APL antibody (ACL and LA) are persistently positive plus other causes and contributory factors are considered.
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Other features Thrombocytopenia Livedo reticularis Sterile endocarditis with embolism Young arterial stroke and MI Catastrophic APS- high fatality due to extensive microvascular thrombosis
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Pathogenesis Pr C resistance Vascular endothelial dysfunction Impaired fibrinolytic activity Thrombosis in the utero-placental vasculature Multifactorial Auto-immune
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This note was uploaded on 12/24/2011 for the course STEP 1 taught by Professor Dr.aslam during the Fall '11 term at Montgomery College.

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Guidelines APS Journal - Guidelines on the investigation...

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