Haemolytic anaemias1

Haemolytic anaemias1 - Haemolyticanaemias...

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Haemolytic anaemias Dr. Suhair Abbas Ahmed
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Haemolytic anaemias (HAs) HAs are defined as those anaemias  which result from an  increase  in the rate  of  red cell destruction.    any condition which leads to a  reduction in the mean lifespan of the red  cell is a  haemolytic disorder.
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Because of  erythropoietic hyperplasia  and  anatomical  extension  of bone marrow, red  cell destruction may be increased several fold  before the patient become anaemic  ---  compensated haemolytic anaemia. The normal adult marrow, after full expansion,  is able to produce red cells at  6-8 times  the  normal rate. Therefore HA may not be seen until the red  cell lifespan is  less than 30 days.
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Classification of HA The HA can be classified in several different  ways:   1-  Site of haemolysis : Extravascular  haemolytic disorders  -macrophages of the RES Intravascular  haemolytic disorders- within the  circulatory system In many of the cases there is a  combination  of both extra  and  intravascular haemolysis.
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Extravascular haemolysis Red cell destruction  usually occurs in the  cell of the RES.
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Intravascular haemolysis Destruction of red  cells occur inside  the blood vessels.
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 2-  Site of defect : Intrinsic defect  (intracorpuscular) structural or functional defect within the  red cell. Extrinsic defect 
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Haemolytic anaemias1 - Haemolyticanaemias...

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