Haemopoiesis Clinical application 3.57.51 PM

Haemopoiesis Clinical application 3.57.51 PM - Haemopoiesis...

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Haemopoiesis Clinical application Dr. Tariq M. Roshan Department of Hematology PPSP
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Introduction Life span Granulocytes Erythrocytes Platelets Lymphocytes
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Introduction Stem cells Self renewal Plasticity Progenitor cells Developmentally-restricted cells Mature cells Mature cell production takes place from the more developmentally-restricted progenitors
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Cell hierarchy (Haemopoiesis schematic representation)
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Sites of Haemopoiesis Yolk sac Liver and spleen Bone marrow Gradual replacement of active (red) marrow by inactive (fatty) tissue Expansion can occur during increased need for cell production
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Stem cells Self-renewal Normally in G 0 phase of cell cycle The capacity for self-reproduction is vastly in excess of that required to maintain cell production for normal lifetime As cells increase in number they differentiate as well Multipotentiality Capacity to generate cells of all the lymphohaemopoietic lineages
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Progenitor cells Encompasses from immediate progeny of stem cells to cells committed to one differentiation lineage Progenitor cells become progressively more restricted in their differentiation and proliferation capacity Late progenitor cells eventually restricted to one lineage
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Regulation of Haemopoiesis There should be a balance between cell production and cell death except at the times of requirement Controlled cell death Controlled cell production
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Regulation of Haemopoiesis Local environmental control Stromal cell mediated Haemopoiesis Haemopoietic growth factors (Humoral regulation) Apoptosis
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Interaction of stromal cells, growth factors and haemopoietic cells
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Local and Humoral regulation of Haemopoiesis
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Haemopoietic growth factors
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