HYPERCALCEMIA - AnjaliGupta,MD Overview Hypercalcemia D/D...

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Anjali Gupta , MD
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Overview y Hypercalcemia D/D y Hypercalcemia from Immobilization 1. Physiology 2. Literature y Hypercalemia from Rhabdomyolysis
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Calcium Homeostasis 6 -10gm/day
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Hypercalcemia Southern Medical Journal • Volume 99, Number 4, April 2006
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Response to Hypercalcemia
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Hypercalcemia from Immobilization y What is considered immobolization? y Time period of onset? y Severity? y Diagnostic Test? y Treatment
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Disclaimer y Paucity of literature y Observational study y Anecdotal and retrospective data
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History of Bed Rest/Immobilization y In the nineteenth century, bed rest was introduced as a medical treatment y Any adverse consequences of this therapy were attributed to the medical condition that sent one to bed in the first place y During the polio epidemic of the first half of the twentieth century, this therapy came to question y Don Whedon and his group (Dietrick et al. 1948) wondered whether the increased excretion of calcium and bone loss in poli0 victims was due to the disease or the resulting immobilization Eur J Appl Physiol (2007) 101:143–194123
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History of Bed Rest/Immobilization y Experiment 30 healthy medical student were put to bed rest y Result were similar to polio victims osteoporosis y During World War II that men who were made ambulatory soon after surgery ,recovered faster y Last half of the twentieth century finally saw a gradual reversal of the practice of using bed rest as medical treatment
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Hypercalcemia of Immobilization y First described by 1941 by Albright in a teenager with fracture y Incidence 11 22% in SCI group and 20 30% in immobilized adults sec to fractures in 2 case series y Usually develops 4 6 weeks post trauma (1 week 16weeks) y May remain elevated for upto 12 months depending upon mobilization
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This note was uploaded on 12/24/2011 for the course STEP 1 taught by Professor Dr.aslam during the Fall '11 term at Montgomery College.

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HYPERCALCEMIA - AnjaliGupta,MD Overview Hypercalcemia D/D...

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