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Introduction to Genetics-15.12.02 3.57.51 PM

Introduction to Genetics-15.12.02 3.57.51 PM -...

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    Introduction to Genetics Dr Narazah Mohd  Yusoff MBBS(Mal), DCP,  MMed Haem.(Lond) Director,  Human Genome  Center.
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Introduction Molecular biology techniques – revolutionized  diagnosis and management Major impact on all specialties, advances  ahead of therapeutic developments Haematology – first to embrace  Hb, chromosomal rearrangements, growth  factors, oncogenes, molecular therapeutics
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The History of Modern  Genetics Mendel and basic genetic principles  Modern era of genetics
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Mendel and basic genetic  principles Austrian monk, Gregor Mendel (1822- 1884) Single-handedly Proposed : parent plants always had 2  “factors”, but only 1 :”factor” from each  parent passed on to each individual of  the next generation Today, Mendel’s “factors” - genes
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Modern era 1910 1949 1953 1970 1980 1985 Fruit fly, TH Morgan L Pauling – “molecular disease” Watson & Crick – “double helix” PCR, Kary Mullis
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Studying DNA in people “It runs in the family” How to prove certain conditions are  genetic? Twin studies Determining  which genes are involved Picking a control group Impact of Human Genome Project
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How does DNA affect you? Ethics - scientists working on reading  and manipulating information in DNA.  Their discoveries – many ethical  dilemmas
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You are the parent You and your husband have been trying to have  a girl for 15 years. Instead, you have had 5 boys. At a very early  stage of pregnancy, you discover another boy is  on the way. If there was a genetic treatment to  change the gender of your fetus, would you use  it? 
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You are the Doctor Your patient has a f/hx of colon cancer,  Otherwise she is physically normal.  She requests genetic tests. Results indicate  that  there is a 15% chance she will develop colon  cancer in the next 20 years. It is your job  to advise your patient. You do not want to  alarm your patient about these inconclusive  results. Do you tell her that she is at risk? 
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You are the patient When you were just a baby, your grandfather  died of Huntington's disease. Huntington's is a  debilitating mental disease that develops in  middle age and often results in death before  the age of 50 and there is no known cure for  the disease. You know that there is a chance  that you carry the Huntington's gene. There is a simple genetic test that can determine whether  you are a carrier. Do you get tested? or is  ignorance bliss? 
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 You are the Judge You have just finished listening to the closing  arguments of a trial and you go to your  chambers to make a decision. The attorneys for 
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