Meningitis 2006 - Meningitis Bacterial Viral ( aseptic) TB...

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Unformatted text preview: Meningitis Bacterial Viral ( aseptic) TB Fungal Chemical Parasitic ? Carcinomatous Meningitis Definition Bacterial meningitis is an inflammatory response to bacterial infection of the pia- arachnoid and CSF of the subarachnoid space Epidemiology Incidence is between 3-5 per 100,000 More than 2,000 deaths annually in the U.S. Relative frequency of bacterial species varies with age. Meningitis Epidemiology Neonates (< 1 Month) Gm (-) bacilli 50-60% Grp B Strep 20-40% Listeria sp. 2-10% H. influenza 0-3% S. pneumo 0-5% Meningitis Epidemiology Children (1 month to 15 years) H. influenzae 40-60% Declining dramatically in many geographic regions N. meningitidis 25-40% S. pneumo 10-20% Meningitis Epidemiology Adults (> 15 years) S. pneumo 30-50% N. Meningitidis 10-35% Major cause in epidemics Gm (-) Bacilli 1-10% Elderly S. aureus 5-15% H. influenzae 1-3% >60 include Listeria, E. coli, Pseudomonas Meningitis Pathogenesis Majority of cases are hematogenous in origin Organisms have virulence factors that allow bypassing of normal defenses Proteases Polysaccharidases Meningitis Pathology and Pathogenesis Sequential steps allow the pathogen into the CSF Nasopharyngeal colonization Nasopharyngeal epithelial cell invasion Bloodstream invasion Bacteremia with intravascular survival Crossing of the BBB and entry into the CSF Survival and replication in the subarachnoid space Meningitis...
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This note was uploaded on 12/24/2011 for the course STEP 1 taught by Professor Dr.aslam during the Fall '11 term at Montgomery College.

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Meningitis 2006 - Meningitis Bacterial Viral ( aseptic) TB...

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