Motor_Neuron_Disease

Motor_Neuron_Disease - Motor Neuron Disease Kefah Al-Hayek...

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Motor Neuron Disease Kefah Al-Hayek, MD J.U.S.T.
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Definitions Motor neuron diseases: Progressive degeneration and loss of motor neurons in the spinal cord with or without similar lesions in the motor nuclei of the brainstem or the motor cortex Motor neuron disease = Amyotrophic lateral sclerosis Spinal muscular atrophy: Only lower motor neuron signs
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A myo trophic lateral sclerosis (ALS) A = without Myo = Muscle Trophic = Nourishment Lateral = side of the spinal cord Sclerosis = Hardening or scaring
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ALS Also known as Lou Gehrig’s disease Degeneration of UMN and LMN Accuracy of clinical diagnosis ~ 95%
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Epidemiology Worldwide roughly the same prevalence 50 X lO -6 No identified consistent risk factors related to occupation, trauma, diet, or socioeconomic status Generally begins in 30-60s 5% of cases are familial in an autosomal dominant pattern 20% of familial cases map to ch. 21; mutations in the gene for superoxide dismutase (SOD) Dementia and parkinsonism seem to increase in first- degree relatives of patients with ALS
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This note was uploaded on 12/24/2011 for the course STEP 1 taught by Professor Dr.aslam during the Fall '11 term at Montgomery College.

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Motor_Neuron_Disease - Motor Neuron Disease Kefah Al-Hayek...

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