Multiple Myeloma presentation

Multiple Myeloma presentation - Multiple Myeloma Multiple...

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Unformatted text preview: Multiple Myeloma Multiple Myeloma Presented by: Mike Lynch Outline of Presentation Outline of Presentation • • • • • • Multiple myeloma Statistics Causes Symptoms Prognosis Treatment options Multiple Myeloma Multiple Myeloma (myeloma or plasma cell myeloma) • Hematological cancer • Plasma cells – White blood cells – Immune system – Bone marrow How Plasma Cells Work How Plasma Cells Work • Develop from stem cells in bone marrow • Stem cells develop into B cells (B lymphocytes) • Antigens enter body then B cells develop into plasma cells • Produce antibodies Normal Cell (5%) Normal Cell (5%) Myeloma Cells (10%) Myeloma Cells (10%) What Causes Myeloma Cells To Grow? What Causes Myeloma Cells To Grow? • Adhesion molecules • Stromal cells Interactions: – Cytokins (chemical messengers) – Growth factors that promote angiogenesis – Inactivated immune system Statistics Statistics • Second most prevalent blood cancer • Approximately 1% of all cancers and 2% • • • • of all cancer deaths. 45,000 currently have multiple myeloma 14,600 new cases of myeloma each year. Responsible for more than 10,000 deaths in the United States annually. 5 year survival rate http://www.multiplemyeloma.org/about_myeloma/2.03.asp Causes Causes • • • • • • • Is not known for sure Decline in the immune system Biological factors Certain occupations Exposure to certain chemicals Exposure to radiation Virus Symptoms Symptoms • Abnormal proteins – Blood and urine – Polyclonal to Monoclonal proteins • High level of calcium in blood – – – – – – Excessive thirst and urination Sleepiness Constipation Nausea Loss of appetite Mental confusion Symptoms Continued Symptoms Continued • • • Anemia Fatigue Bone pain – – Back Ribs • Unexplained bone fractures • Repeated infections – Pneumonia – Bladder and kidney infection – Urinary tract infection • Weight loss • Weakness and numbness in limbs Screening and Diagnosis Screening and Diagnosis • • • • • Blood and urine tests X­rays Magnetic Resonance Imaging (MRI) Computerized Tomography (CT) Bone marrow examination Staging Staging • Stage 1 – Low amount of myeloma • Stage 2 – Medium amount of myeloma • Stage 3 – High amount of myeloma •A – Normal kidney function •B – Abnormal kidney function Treatment Options Treatment Options • • • Chemotherapy Stem cell transplantation Radiation therapy • Bortezomib (Velcade) • Thalidamide Thank you for your time Thank you for your time Any Questions ? ...
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