{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

myeloma_and_the_kidney

myeloma_and_the_kidney - 1 MultipleMyeloma MultipleMyeloma...

Info icon This preview shows pages 1–11. Sign up to view the full content.

View Full Document Right Arrow Icon
1 Tuesday Case Conference Tuesday Case Conference
Image of page 1

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
2 Multiple Myeloma Multiple Myeloma Myeloma related renal failure Treatment
Image of page 2
3 Myeloma A clonal disorder of plasma cells Affects 1 in 300,000 1% of all new malignancies (16,000 per year) 10% of all new hematologic malignancies 2% of all cancer deaths (11,3000 per year) Median age of onset: 66 Most common hematologic malignancy in  African Americans
Image of page 3

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
4 Development of Myeloma Cells Transformation of a  normal B cell into a  malignant plasma cell Environmental/occupation al exposures have been  implicated Cytokines IL-6, RANK, TNF VEGF
Image of page 4
5 Multiple Myeloma - diagnosis Clonal plasma cells >10% on bone marrow  biopsy or (in any quantity) in a biopsy from  other tissues (plasmacytoma) A monoclonal protein (paraprotein) in either  serum or urine Evidence of end-organ damage
Image of page 5

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
6 Structure of immunoglobulin Nelson DL, Cox MM. Lehninger principles of biochemistry, 4th ed. WH Freeman pub. New York 2005.
Image of page 6
7 Serum Protein Electrophoresis Astion ML, Rank J, Wener MH, Torvik P, Schneider JB, Killingworth LM. Electrophoresis-tutor: an image-based personal computer program that teaches clinical interpretation of  protein electrophoresis patterns of serum, urine and CSF. Clin chem. 1995 Sep;41(9):1328-32
Image of page 7

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
8 Immunofixation Electrophoresis  (IFE) Astion ML, Rank J, Wener MH, Torvik P, Schneider JB, Killingsworth LM. Electrophoresis-tutor: an image based personal computer program that teaches clinical  interpretation of protein electrophoresis patterns of serum, urine, and CSF. Clin Chem. 1995 Sep;41(9):1328-32.
Image of page 8
9 Frequency of isotypes of heavy and light chains produced by non–immunoglobulin (Ig) M myelomas
Image of page 9

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
10 Staging and Prognostic Factors
Image of page 10
Image of page 11
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern