myeloma_and_the_kidney

Myeloma_and_the_kidn - 1 MultipleMyeloma MultipleMyeloma Treatment 2 Myeloma Affects1in300,000 1%(16,000peryear 10% 2%ofallcancerdeaths(11,3000per

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1 Tuesday Case Conference Tuesday Case Conference
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2 Multiple Myeloma Multiple Myeloma Myeloma related renal failure Treatment
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3 Myeloma A clonal disorder of plasma cells Affects 1 in 300,000 1% of all new malignancies (16,000 per year) 10% of all new hematologic malignancies 2% of all cancer deaths (11,3000 per year) Median age of onset: 66 Most common hematologic malignancy in  African Americans
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4 Development of Myeloma Cells Transformation of a  normal B cell into a  malignant plasma cell Environmental/occupation al exposures have been  implicated Cytokines IL-6, RANK, TNF VEGF
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5 Multiple Myeloma - diagnosis Clonal plasma cells >10% on bone marrow  biopsy or (in any quantity) in a biopsy from  other tissues (plasmacytoma) A monoclonal protein (paraprotein) in either  serum or urine Evidence of end-organ damage
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6 Structure of immunoglobulin Nelson DL, Cox MM. Lehninger principles of biochemistry, 4th ed. WH Freeman pub. New York 2005.
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7 Serum Protein Electrophoresis Astion ML, Rank J, Wener MH, Torvik P, Schneider JB, Killingworth LM. Electrophoresis-tutor: an image-based personal computer program that teaches clinical interpretation of  protein electrophoresis patterns of serum, urine and CSF. Clin chem. 1995 Sep;41(9):1328-32
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8 Immunofixation Electrophoresis  (IFE) Astion ML, Rank J, Wener MH, Torvik P, Schneider JB, Killingsworth LM. Electrophoresis-tutor: an image based personal computer program that teaches clinical  interpretation of protein electrophoresis patterns of serum, urine, and CSF. Clin Chem. 1995 Sep;41(9):1328-32.
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9 Frequency of isotypes of heavy and light chains produced by non–immunoglobulin (Ig) M myelomas
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10 Staging and Prognostic Factors
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This note was uploaded on 12/24/2011 for the course STEP 1 taught by Professor Dr.aslam during the Fall '11 term at Montgomery College.

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Myeloma_and_the_kidn - 1 MultipleMyeloma MultipleMyeloma Treatment 2 Myeloma Affects1in300,000 1%(16,000peryear 10% 2%ofallcancerdeaths(11,3000per

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