Neurotransmitters

Neurotransmitters - Neurotransmitters Haytham Eloqayli

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Neurotransmitters Haytham Eloqayli
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Mechanism of Action of Selective  Monoaminergic Reuptake Inhibitors   Figure A SIGMA-ALDRICH
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MAO The primary monoamine neurotransmitters are dopamine, norepinephrine and serotonin. Dopamine and norepinephrine are catecholeamines, whereas serotonin is an indolamine. Dopamine & epinephrine are primarily inhibitory neurotransmitters that produce arousal
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Dopamine phenylalanine phenylalanine hydroxylase (liver) tyrosine (enter the brain via large neutral amino acid transporter ) tyrosine hydroxylase DOPA A romatic A mino A cid D ecarboxylase DOPAMINE
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Dopamine dopaminergic neurons: originate mainly from 3 areas in the brain: Substantia nigra, Ventral tegmental area (VTA), Hypothalamus 4 main dopaminergic tracts: Nigrostriatial tract ( accounts for most of the brain's dopamine) T uberoinfundibular tract (tonic inhibition effect on the release of prolactin from pituitary) Mesolimbic tract and mesocortical tract (VTA)
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Dopamine (inactivation and degradation) synaptic activity is primarily terminated by re-uptake into the pre-synaptic neuron terminal. Dopamine repackaged into vesicles for reuse or catabolized by MonoAmineOxidase (MAO) in the pre- synaptic terminal. only about 10% of synaptic catecholamine is catabolized in the synapses by the enzyme Catechol-O- MethylTransferase (COMT)
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Dopamine decreased levels → Parkinson disease,
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Neurotransmitters - Neurotransmitters Haytham Eloqayli

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