oralclefts_environment_exposure_genetic_variation_candidate

oralclefts_environment_exposure_genetic_variation_candidate...

Info iconThis preview shows pages 1–10. Sign up to view the full content.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: Oral Clefts, Environmental Exposures, and Genetic Variation of Candidate Genes Edward Lammer, MD Eric Lloyd David Iovannisci, PhD Poulina Uddin Shira Kupperman Dorian Ramirez Gary Shaw, DrPH CA Birth Defects Monitoring Pgm. Richard Finnell, PhD IBT, Texas A&M Univ. Oral Clefts, Environmental Exposures, and Genetic Variation of Candidate Genes Multivitamins with folate folate-related metabolism and transport : MTHFR, CBS, FR-alpha, RFC1 Xenobiotic metabolizing enzymes phase 1 : CYP2D6, NAT1, NAT2, EPHX1 phase 2 : GSTT1, GSTM1, GSTP1, NAT1 Isolated cleft lip cleft palate Maternal smoking CA 87-89 Maternal smoking from conception - 3 months Odds ratio [95% CI] Any smoking 1.6 [1.1-2.4] 20 cigs/day 2.4 [1.2-5.1] 1-19 cigs/day 1.5 [1.0-2.2] Isolated cleft palate Maternal smoking CA 87-89 Maternal smoking from conception - 3 months Odds ratio [95% CI] Any smoking 1.6 [1.0-2.6] 20 cigs/day 2.7 [1.1-6.3] 1-19 cigs/day 1.3 [0.78-2.3] GSTM1/GSTT1/Albumin Analysis Frequencies and risks of Glutathione- S- transferase genotypes CA 87-89 GSTM1 Isolated Cleft Lip Genotypes Cleft Palate Cleft Palate Controls GSTM1+ 149 70 146 Null 149 55 148 [50%] OR = 0.99 [0.71-1.4] OR = 0.78 [0.50-1.2] GSTT1 Isolated Cleft Lip Genotypes Cleft Palate Cleft Palate Controls GSTT1+ 250 106 250 Null 48 19 44 [15%] OR = 1.1 [0.68-1.7] OR = 1.0 [0.54-1.9] Any Maternal Smoking, GSTT1 Genotype, and Cleft Lip Risk Isolated Cleft Lip Cleft Palate Genotypes Any Smoking Nonsmokers OR = 2.9 (1.1-8.5) OR = 0.92 (0.52-1.6) GSTT1 null GSTT1 + OR = 1.5 (1.0-2.3) Reference Any Maternal Smoking, GSTT1 Genotype, and Cleft Palate Risk Isolated Cleft Palate Genotypes Any Smoking Nonsmokers OR = 2.3 (0.61-8.2) OR = 0.94 (0.43-1.9) GSTT1 null GSTT1 + OR = 1.5 (0.89-2.5) Reference Any Maternal Smoking,...
View Full Document

Page1 / 28

oralclefts_environment_exposure_genetic_variation_candidate...

This preview shows document pages 1 - 10. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online