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# PAH1 - What defines vascular resistance If Q = flow P =...

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What defines vascular resistance? If: Q = flow P = pressure R = resistance Then we can say: Q = P 1 –P 2 / R

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P 1 P 2 Where does the most flow occur? P 1 = 100 and P 2 = 90 Or P 1 = 25 and P 2 = 10
P 1 P 2 Where does the most flow occur? P 1 = 100 and P 2 = 90 Or P 1 = 25 and P 2 = 10

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Once again, if this is the relationship that defines resistance, what is the most critical determinant of resistance in the circulation? R = 8nl / II r 4 Viscosity? Vessel length? Radius?
R = 8nl / II r 4 VASCULAR RADIUS

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UNIQUE CHARACTERISTICS OF THE PULMONARY CIRCULATION THE PULMONARY CIRCULATION MUST, AT ALL TIMES, ACCEPT THE ENTIRE CARDIAC OUTPUT THE PULMONARY CIRCULATION IS SUBSERVED BY A VENTRICLE THAT CANNOT GENERATE HIGH PRESSURE VASCULAR RESISTANCE IN THE PULMONARY CIRCULATION IS ONE- TENTH THAT OF THE SYSTEMIC CIRCULATION WITHIN THE PULMONARY CIRCULATION, BLOOD FLOW MUST BE DIRECTED TO WELL VENTILATED (OXYGENATED) ALVEOLI, THAT IS, VENTILATION MUST BE MATCHED WITH PERFUSION
So – what keeps resistance low when flow is increased?

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What does this graph depict?
Pulmonary Hypertension: The normal pressure in the pulmonary circulation is 25/10 mm Hg with mean pressure of 15 mm Hg. Pulmonary hypertension is said to be present if the pulmonary mean arterial pressure exceeds 25 mm Hg at rest and/or 30 mm Hg with exercise.

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Pulmonary Hypertension: Post-capillary:
Pulmonary Hypertension: Post-capillary: Left ventricular failure

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PAH1 - What defines vascular resistance If Q = flow P =...

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