Regulation_of_Phosphate_Transport_in_Proximal_Tubule_1

Regulation_of_Phosphate_Transport_in_Proximal_Tubule_1 -...

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Unformatted text preview: TmP/GFR = maximum reabsorption of PO 4 per unit volume of GFR FE PO4 = U PO4 /P PO4 / U creat /P creat 1 - FE PO4 = TRP Assuming P PO4 = [PO4] GFR TmPO4/GFR = TRP X P PO4 • Tubular reabsoption of phosphate (TRP) • Tubular maximal reabsoption rate of phosphate to GFR (TmP/GFR) • TRP =99.9% • TmP/GFR = TRP x Plasma Phos = 0.999 x 0.93 mmol/L (converted from 2.9 mg/dL) = 0.93 mmol/L Regulation of Phosphate Transport in Proximal Tubule Alexander Usorov, MD 11/25/08 Overview • Role of phosphorus • Proximal nephron transport mechanism • Sodium-hydrogen exchanger regulatory factor-1 (NHERF1) • Fibroblast Growth Factor (FGF 23) Importance of Phosphorus • Component of hydroxyapatite, which is the major component of bone mineral • Present in nucleic acids, bioactive signaling proteins, phosophorylated enzymes, and cell membranes • Deficiency in phosphorus leads to – Impaired bone mineralization (osteomalacia or rickets) – Abnormal RBC, WBC, Plt fxn – Impaired cell membrane integrity (rhabdo) – Impaired cardiac output Phosphorus Metabolism 1500mg 1100mg 200mg 200mg Phosphorus reabsorption...
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This note was uploaded on 12/24/2011 for the course STEP 1 taught by Professor Dr.aslam during the Fall '11 term at Montgomery College.

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Regulation_of_Phosphate_Transport_in_Proximal_Tubule_1 -...

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