Renal Artery Stenosis 10-11

Renal Artery Stenosis 10-11 - RENAL ARTERY STENOSIS Grand...

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RENAL ARTERY STENOSIS Grand Rounds 10/11/2011
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ARAS Prevalence- 0.5% overall population, 5.5% in ckd pts No correlation between ischemic nephropathy and severity of stenosis Increased risk of vascular events- CAD 67% vs 25%, CVA-37% vs 12%, PVD-56% vs 13%, CKD- 25% vs 2% (medicare database) Renovascular htn 5 yr survival 45%, 18% once on dialysis
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RESISTIVE INDEX Kidney International (2006) 70, 1543–1547
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FACTORS THAT PLAY ROLE IN RVD VEGF has been shown in animal models to be crucial for preservation of renal microvasculature and promotes vascular proliferation and endothelial repair. Hypoxia-inducible factor (HIF)-1, matrix metalloproteinases (MMP)-2, MMP-9, membrane- type MMP (MT-MMP), plasminogen activator inhibitor (PAI)-1, tissue transglutaminase (tTG), and transforming growth factor (TGF)-beta are other factors shown to play a role.
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Cardiotonic steroids are a group of steroids recently discovered in the plasma and urine of pts with CHF, CKD and MI. Object of the study is to test the effect of renal
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Renal Artery Stenosis 10-11 - RENAL ARTERY STENOSIS Grand...

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