Rhabdomyolysis 1

Rhabdomyolysis 1 - Sheena Surindran Background...

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Sheena Surindran
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` Background ` Pathophysiology ` Treatment ` Role of RRT ` New developments
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` Rhabdomyolysis was first described in 1941 in the London Blitz. ` Characteristics by the leakage of muscle-cell contents, including electrolytes, myoglobin, and other sarcoplasmic proteins ( creatine kinase, aldolase, LDH, AST, and ALT) into the circulation.
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` Acute kidney injury as a complication of rhabdomyolysis represents about 7 to 10% of all cases of acute kidney injury in the United States. ` Majority of patients with Rhabdomyolysis will recover.
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` Intra renal vasoconstriction ` Direct and ischemic tubular injury- by Fe induced lipid peroxidation and cytotoxity.* ` Tubular obstruction * Demonstrated by in vivo studies on rat prox tubular segment- Univ of washington . J Clin Invest. 1992 Mar;89(3):989-95
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` Measured urinary excretion of isoprostanes in 8 patients admitted with rhabdomyolysis vs control -7 ckd(non dialysis) + 10 normal ` Increased in patients with Rhabdo (46pgm/ml creatinine cl) vs 16 pgm/ml in control grp.
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Rhabdomyolysis 1 - Sheena Surindran Background...

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