student bone metabolism ortho

student bone metabolism ortho - BoneMetabolism CMRobinson...

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Bone Metabolism CM Robinson Senior Lecturer Royal Infirmary of Edinburgh
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Outline Normal bone structure Normal calcium/phosphate metabolism Presentation and investigation of bone  metabolism disorders Common disorders of bone metabolism
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Normal Bone Structure What are the normal types of bone in  the mature skeleton? Lamellar Cortical Cancellous Woven Immature Healing Pathological
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What is the composition of bone? The matrix 40% organic  Type 1 collagen (tensile strength) Proteoglycans (compressive strength) Osteocalcin/Osteonectin Growth factors/Cytokines/Osteoid 60% inorganic Calcium hydroxyapatite   The cells  osteo-clast/blast/cyte/progenitor
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Bone structure Structure of lamellar bone? Structure of woven bone?
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Bone turnover How does normal bone grow……. . In length? In width? How does normal bone remodel? How does bone heal?
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Bone turnover What happens to bone………. in youth? aged 20-40’s? aged 40+? aged over 70?
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Calcium metabolism What is the recommended daily intake? 1000mg What is the plasma concentration? 2.2-2.6mmol/L How is calcium excreted? Kidneys - 2.5-10mmol/24 hrs How are calcium levels regulated? PTH and vitamin D (+others)
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Phosphate metabolism Normal plasma concentration? 0.9-1.3 mmol/L Absorption and excretion? Gut and kidneys Regulation Not as closely regulated as calcium but  PTH most important
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PTH Physiological role Production related to plasma calcium  levels Control of calcium levels target organs bone - increased Ca/PO4 release kidneys increased reabsorption of Ca increased excretion of PO4 gut - indirect increase in calcium reabs by  stimulting activation of vitamin D metabolism
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This note was uploaded on 12/24/2011 for the course STEP 1 taught by Professor Dr.aslam during the Fall '11 term at Montgomery College.

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student bone metabolism ortho - BoneMetabolism CMRobinson...

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