Zinc - Zinc: another miracle micronutrient Dr. Pushpa Raj...

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Zinc: another miracle micronutrient Dr. Pushpa Raj Sharma Professor of Child Health Institute of Medicine
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Until 1961 it was believed that zinc deficiency in humans could never occur. In 1958, a 21 year old male patient in the Iranian city of Shiraz presented with dwarfism, hypogonadism, hepatosplenomegaly, rough and dry skin, mental lethargy, geophagia, and iron deficiency anaemia. In the following three months 10 more patients with a similar illness were seen in the same hospital . Prasad AS, Halsted JA, Nadimi M. Syndrome of iron deficiency anemia, hepatosplenomegaly, hypogonadism, dwarfism and geophagia. Am J Med 1961; 31: 532-546
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Zinc : Its role in human body 3 rd most abundant trace element in body There are no zinc stores in the body to mobilize from, and in 16 hours an animal can be deficient with rapid effects. Functions: Metabolism (functions in over 200 enzymatic reactions) Antioxidant function Immunity and Wound healing Fetal Growth and Development Production of brain neurotransmitters
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Zinc and its effect When pregnant mice were fed a diet moderately deficient in zinc, their offspring exhibited a malfunctioning immune system for the first six months of life. More alarming, the second and third generations also showed signs of poor immunity - even though they were fed a zinc-plentiful diet. Jean Carper, writing in Jean Carper's Total Nutrition Guide, in reference to zinc studies done at U.C. Davis
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Problem Large sections of populations in Africa and Asia are at risk of dietary zinc deficiency and resulting high rates of stunting. International Zinc Nutrition Consultative Group (I ZiNC G). Assessment of the risk of zinc deficiency in populations. Food Nutr Bull 2004;25:S130-62 30- 50% of children residing in low income setting have low serum or plasma zinc Overall poor dietary intake Low intake of animal source of food High consumption of phytates Increased fecal losses during diarrheal illnesses
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Symptoms of Zinc Deficiency Delayed puberty in adolesce Rough skin Poor appetite Mental lethargy Delayed wound healing Short stature Diarrhea Pneumonia Stretch marks (striae ) Delayed skeletal maturation and defective mineralization of bone (monkeys) Weight loss Intercurrent infections Hypogonadism in males Lack of sexual development in females Growth retardation Dwarfism
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Symptoms of Zinc Deficiency White spots on fingernails Reduction in collagen turnover and synthesis (in chicks) Reduction in collagen (in humans) Poor Immune system Acne Cross-linking of collagen Hyaluronic acid abnormalities (in swine) Defective connective tissue Macular degeneration Cataracts (in salmon )
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Zinc Deficiency Severe Deficiency Acrodermatitis enteropathica Syndrome of hypogonadism, stunting, anemia, anorexia and hepatosplenomegaly. Mild/Subclinical Deficiency
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Zinc - Zinc: another miracle micronutrient Dr. Pushpa Raj...

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