Chapter 6 Homeostasis, Part 1

Chapter 6 Homeostasis, Part 1 - Ch 6 Communication...

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Ch. 6: Communication, Integration & Ch. 6: Communication, Integration & Homeostasis Homeostasis Describe cell to cell communication Electrical or Chemical only Explain signal transduction Review homeostasis Goals N.B.: Running Problem, Diabetes Mellitus
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Cell to Cell Communication Cell to Cell Communication 75 trillion cells (In Scientific Notation??) 4 basic methods of cell to cell communication (p 175): 1. Direct cytoplasmic transfer (Gap Junctions) 2. Contact dependant signals (Surface Molecules) 3. Short distance (local diffusion) 4. Long distance ( through either chemical or electrical signals) Cell receiving signal = ? receptors
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1. Gap Junctions for Direct 1. Gap Junctions for Direct Cytoplasmic Transfer Cytoplasmic Transfer Connexins from each cell form connexon (channel) Gate open cytoplasmic bridges form functional syncytium Ions and small molecules can pass freely Transfer of electrical and chemical signals (ubiquitous, but particularly in heart muscle and smooth muscle of GI tract)
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2. Contact-Dependent Signals 2. Contact-Dependent Signals Require cell-cell contact Surface molecules bind CAMs – Cell Adhesion Molecules Bidirectional Communication Possible
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3. Short distance (local diffusion) 3. Short distance (local diffusion) Mode of transport diffusion (slow) Histamines, cytokines, eicosanoids (more later) Many act as both paracrines and autocrines Paracrines and Autocrines (Chemical signals secreted by cells) Para- = next to Auto- = self
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4. Long Distance
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Chapter 6 Homeostasis, Part 1 - Ch 6 Communication...

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