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Chapter 15 Blood Flow, Part 2

Chapter 15 Blood Flow, Part 2 - Keypoints 1 Blood...

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1. Blood pressure (BP) and Regulation 2. Exchange at capillaries 3. Lymphatic system 4. Cardio-vascular diseases Keypoints
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Review: R = R = π π r r 4 8 8 L L η η R = Resistance L = Length of “pipe” η = = viscosity r = radius
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Control of Blood Flow 1. Local control: By paracrines O 2 CO 2 NO (in erection) In the heart, adenosine serves as a paracrine to dilate coronary arteries Others: histamine, ↓ O 2 and ↑ CO 2 arteriolar dilation The ↑ flow is hyperemia
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Control of blood flow, cont’d 2. Endocrine: ANP and Angiotensin II (Chapt 20) 3. ANS (mostly sympathetic): NE on α receptors vasoconstriction E on β 2 receptors vasodilation (F or F)
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Distribution of Blood
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Exchange at the Capillaries Capillaries are anatomically designed for exchange Capillaries are anatomically designed for exchange Continuous Continuous (leaky junctions) (leaky junctions) Fenestrated Fenestrated (kidney and intestine) (kidney and intestine) Sinusoids Sinusoids in liver, bone marrow and kidney in liver, bone marrow and kidney Capillaries in the brain are less leaky and are surrounded by Capillaries in the brain are less leaky and are surrounded by astrocytes and pericytes astrocytes and pericytes BBB BBB Fig 15-16
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Exchange at the Capillaries Capillary blood flow: Greatest total Capillary blood flow: Greatest total cross sectional area cross sectional area
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