SCHIZOPHRENIA - SCHIZOPHRENIA A bit of history Hideyo...

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Unformatted text preview: SCHIZOPHRENIA A bit of history Hideyo Noguchi, 1911: Syphillis (delusions, grandiosity, impulsivity, altered thought structure) is due to bacterium. Emil Kraeplin, 1919: dementia praecox (paranoia, grandiose delusions, auditory hallucinations, abnormal emotional reg., bizarre thoughts)partly genetic Eugen Bleuler, 1911: key is dissociative thinking; also delusions, hallucinations, affective disturbance, autism. Twin studies Why does one twin become schizophrenic and the other does not? Lower birth weight More physiological distress More submissive, tearful, sensitive Impaired motor coordination Genes Genes scattered across all but 8 chromosomes have been implicated Most important: Neuregulin 1: NMDA, GABA, & Ach receptors Dysbindin: synaptic plasticity Catechol-O-methyl transferase: DA metabol. G72: regulates glutamatergic activity Others: myelination, glial function Paternal age: more cell divisions in sperm Structural changes in brain Larger ventricles Subgroup: inverse correlation between ventricle size and response to drugs Structural changes in brain...
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SCHIZOPHRENIA - SCHIZOPHRENIA A bit of history Hideyo...

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