Eukaryotes G&H-1

Eukaryotes G&H-1 - National Geographic 35 Keeton...

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1 Molecular Biology Part IV: Eukaryotes 3 G. Transposons H. Antibodies
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2 G. Transposons Bacteria Insertion sequences Composite transposons Eukaryotes Maize Peas Flies Humans
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3 Lewin 2000 Genes VII Schematic of Insertion Sequences
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4 Lewin 2000 Genes VII Examples of Insertion Sequences
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5 Lewin 1990 Genes IV
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6 Lewin 1990 Genes IV
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7 Lewin 1990 Genes IV
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8 Science Nov. 2003
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9 Weigel et al. 2003 Science std VRE MRSA VRSA
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10 Weigel et al. 2003 Science
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12 Federoff, N. 1984 Scientific American
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15 Federoff, N. 1984. Scientific American
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16
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17 Weaver 2005 Molecular Biology 3 rd ed.
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20 Federoff, N. 1984 Scientific American
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21 RR, Rr = smooth rr = rough
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22 Bhattacharyya et al. 1990
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23 Bhattacharyya et al. 1990
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24 Bhattacharyya et al. 1990
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25 Bhattacharyya et al. 1990
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26 Lewin 1990 Genes IV
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27 Lewin 1990 Genes IV
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28 Smit & Riggs 1996
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29 H. Antibody diversity B- and T- Lymphocytes: enormous diversity of cell-surface binding proteins
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30 Lennart Nilson National Geographic
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Unformatted text preview: National Geographic 35 Keeton & Gould 1986 Biological Science 4 th ed. 36 37 38 Keeton & Gould 1986 Biological Science 4th ed. 39 Keeton & Gould 1986 Biological Science 4th ed. 40 Experiment by Hozumi & Tonegawa Watson et al. 1987 Mol. Bio. of the Gene 4 th ed. 41 Watson et al. 1987 Molecular Biology of the Gene 42 Weaver 2005 Molecular Biology 3rd ed. Fig. 23-13 43 Weaver 2005 Molecular Biology 3rd ed. Fig 23-14 44 Watson et al. 1987 Mol. Bio. of the Gene 4th ed. 45 Summary: Mechanisms generating antibody diversity 1. Multiple germ-line genes for variable regions (V, D, J) 2. Combinatorial joining (random) of V-J or V-D-J segments 3. Junctional diversity (position) of joining 46 Summary: Mechanisms generating antibody diversity 4. Nucleotide insertion at junctions 5. Somatic hypermutation 6. Combinatorial joining of any heavy chain with any light chain 47 Watson et al. 1987 Molecular Biology of the Gene 48 49...
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Eukaryotes G&H-1 - National Geographic 35 Keeton...

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