12-05-11 Osteogenesis

12-05-11 Osteogenesis - ZOL320 Developmental Biology...

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ZOL320 Developmental Biology December 5, 2011 Osteogenesis Bone: Spongy bone – inside bone (weaker part, where osteoporosis occurs) Compact bone – outer portion of bone (hydroxyl apatite; calcium phosphate – modified extra cellular matrix) Multiple functions of bone : o Support, storage, movement, protection, blood cell production (erythropoeisis), fat storage Bone cell types arise in scleratome, lateral mesoderm, head mesenchyme, and NCC: Osteoblasts : Hyperblastic cells, last a lifetime Osteocytes : Form mature bone (pockets of them), scattered Osteoclasts : Cells which degrade bone (30% of bone turns over per year) Two types of osteogenesis 1. Intramembranous ossification (5%) a. Mesenchyme bone 2. Endochondral ossification (95%) a. Mesenchyme cartilage (structure model) bone A. Intramembranous ossification Starts off in patches of cells, grow out, get closer together and make mature bone Bone specific proteins of matrix o Osteocalcin and ostopotin : Made by osteocytes and allows calcium phosphate (hydroxyapatite) to be deposited in a matrix of protein o They promote mineralization of bone
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This note was uploaded on 12/21/2011 for the course ZOL 320 taught by Professor Kopachik during the Fall '11 term at UCSB.

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12-05-11 Osteogenesis - ZOL320 Developmental Biology...

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