11-09-11 Neuronal Development

11-09-11 Neuronal Development - ZOL 320 Developmental Bio...

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ZOL 320 Developmental Bio November 9, 2011 Neuronal Developmental Mechanisms Axon development in 3 steps: 1. Pathway selection : Directs growth to a region 2. Target selection : Specifies which cells to contact 3. Address selection : Determines which connections will be kept A. Pathway Selection a. Migration directed by molecules in the path promoting or inhibiting extension of the growth cone. a.i. Some molecules work for all - general proteins a.ii. Some work for a small subset a.iii. Axon grows from cell body to target a.iv. Neurons migrate along laminin , but not collagen IV, painted in stripes on a plastic surface a.iv.1. These are general type factors a.iv.2. a.iv.2.a. Giant black thing = clump of neurons a.iv.2.b. They really don’t like certain areas, but they love laminin! (present in a lot of basal lamina) b. Selective repulsion : Another method for directing migration route b.i. Ephrin and semaphorin are novel proteins with specific functions b.i.1. Ephrin is a repellant protein b.i.1.a. Eph receptors in growth cone receive ephrin and signal transduction tells growth cone to stop migration b.i.1.b. Axons prefer areas w/o ephrin
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This note was uploaded on 12/21/2011 for the course BIO 202 taught by Professor Brooks during the Fall '11 term at UCSB.

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11-09-11 Neuronal Development - ZOL 320 Developmental Bio...

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