11-14-11 Neural Crest Cells - ZOL 320 Developmental Bio...

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ZOL 320 Developmental Bio November 14, 2011 Neural Crest Cells Main characteristics: 1. Could be called a 4 th germ layer, only in vertebrates, and responsible for many differences among them, especially craniofacial differences, color, and patterns . a. Antlers, tusks, horns, and modified teeth – neural crest cells 2. Highly pluripotent , forming cell type characteristics of ectoderm and mesoderm 3. Widely dispersed with long migrations along anterior-posterior axis in 4 major groups 4. Highly interactive with cells from other germ layers 5. Main point: Neural crest have been a big target for evolution of development A. Neural crest cell origin and potency a. Two main morphogens are involved: Wnt and BMP b. Arise at neural folds b.i. Notochord induces neural formation and causes production of BMP in neural plate b.ii. Wnt produced in epidermis b.iii. Cells from neural plate regions can switch to neural crest cells c. Migratory cells so they don’t stick to other cells neural crest cells - NO cadherin !
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