11-16-11 Neural Crest Cells Continued

11-16-11 Neural Crest Cells Continued - ZOL 320...

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ZOL 320 Developmental Bio November 16, 2011 Neural Crest Cells Continued A. Neural crest cell origin and potency B. Pathways of migration C. Differentiation properties a. Highly pluripotent , but fate determined from location where they are found (not at formation) b. Main evidence: b.i. Transplantation of the NCCs shows that they’ll differentiate according to the new location b.ii. Mapping of daughter cells from single NCC shows it had high pluripotency c. Specification of NCC fate: c.i. Sympathetic chain cells, can form in culture by giving NCCs FGF c.ii. Adrenal cells (endocrine) made by NCCs by giving glucocorticoids c.iii. Responsive to many types of input d. Cranial derivatives of neural crest d.i. Facial bones d.ii. Meckel’s cartilate (mandible) d.iii. Inner ear d.iv. Hyoid d.v. Thyroid cartilage d.vi. Cricoids cartilage d.vii. Tracheal rings d.vii.1. Comparison of facial bones in fish and humans shows how NCCs can evolve new structures d.vii.2. Neural crest transplant experiment show how important
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