10-28-11 Genes and Develoment II Continued

10-28-11 Genes and Develoment II Continued - ZOL 320...

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ZOL 320 Developmental Bio October 28, 2011 Genes and Development II Continued I. Cellular totipotency – when do cells lose totipotency in development? A. Prospective potency of ES and other stem cells a. Embryonic stem cells: Origin, characteristics, and uses a.i. Main Points: a.i.1. Highly pluripotent cells that arise from cultures of ICM cells a.i.2. Method: ICM separated single cells placed in culture dish containing medium w/ nutrients, salt, fetal calf serum, and a feeder layer of non-dividing embryonic cells a.i.3. ES cells emerge after months of proliferation as undifferentiated dividing cells. a.ii. ES cell characteristics: a.iii. Pluripotency of ES cells? a.iv. Uses of ES cells in research: a.iv.1. To study differentiation in culture with goal controlled differentiation to replace diseased or lost tissue a.iv.1.a. Controlling amount, type of cell in correct arrangement for differentiation is major challenge a.iv.1.b. Problems with ES cells: a.iv.1.b.i. Preventing teratomas is a concern a.iv.1.b.ii. For ES cells used for cell-based therapy (to replace tissue in regenerative medicine) the host immune
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This note was uploaded on 12/21/2011 for the course BIO 202 taught by Professor Brooks during the Fall '11 term at UCSB.

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10-28-11 Genes and Develoment II Continued - ZOL 320...

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