666.01 - Biostatistics 666 Statistical Models in Human...

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Biostatistics 666 Statistical Models in Human Genetics Instructor Gonçalo Abecasis
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Course Logistics Grading Office Hours Class Notes
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Course Objective z Provide an understanding of statistical models used in gene mapping studies z Survey commonly used algorithms and procedures in genetic analysis
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Assessment z 10-12 Weekly Assignments About 60% of the final mark z 2 Half Term Assessments About 40% of the final mark
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Office Hours z Please cross out times for which you are unavailable in the sheet going around z Room M4132 School of Public Health II
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Class Website z PDF versions of notes and problem sets www.sph.umich.edu/csg/abecasis/class/ z Please let me know about any mistakes!
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Course Contents Brief Overview
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Genetic Mapping “Compares the inheritance pattern of a trait with the inheritance pattern of chromosomal regions” Positional Cloning “Allows one to find where a gene is, without knowing what it is.”
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Some of the Topics Covered z Maximum Likelihood z Modeling Genes in Populations z Modeling Genes in Pedigrees
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Modeling Genes in Populations z Hardy Weinberg Equilibrium z Linkage Disequilibrium z The Coalescent z Methods for Haplotyping
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Modeling Genes within Pedigrees z Elston-Stewart algorithm z Lander-Green algorithm z Genetic linkage tests z Checking Genetic Data for Errors z Family Based Association Tests
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Let’s Get Started! The Basics
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Today – Primer In Genetics z How information is stored in DNA z How DNA is inherited z Types of DNA variation z Common designs for Genetic studies
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DNA – Information Store z Encodes the information required for cells and organisms to function and produce new cells and organisms. z DNA variation is responsible for many individual differences, some of which are medically important.
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Human Genome z Multiple chromosomes 22 autosomes Present in 2 copies per individual One maternally and one paternally inherited copy
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This note was uploaded on 12/26/2011 for the course BIO 666 taught by Professor Staff during the Fall '06 term at University of Michigan.

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666.01 - Biostatistics 666 Statistical Models in Human...

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