666.02 - Genes in Populations: Hardy Weinberg Equilibrium...

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Genes in Populations: Hardy Weinberg Equilibrium Biostatistics 666
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Previous Lecture: Primer In Genetics z How information is stored in DNA z How DNA is inherited z Types of DNA variation z Common designs for Genetic studies
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Recommended Reading z Lander and Schork (1994) Genetic Dissection of Complex Traits Science 265: 2037-48 z Paper was written >10 years, well before the human genome was sequenced z Now, studies are facilitated by widespread availability of genetic sequence data (for an example, see http://genome.ucsc.edu/ )
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Important Issues to Consider z What are the specific challenges of genetic studies in humans? z What are common strategies for improving the power of a genetic study? z How can we combine different strategies to achieve cost-effective studies?
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Always Check Data Quality! Study results are only as good as the data available and – as this example shows – things can go wrong!
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Today … z Properties of alleles in a population z Allele frequencies z Genotypes frequencies z Hardy-Weinberg equilibrium
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Alleles z Alternative forms of a particular sequence z Each allele has a frequency, which is the proportion of chromosomes of that type in the population
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Allele Frequency Notation z For two alleles Usually labeled p and q = 1 – p z For more than 2 alleles Usually labeled p A , p B , p C ... … subscripts A, B and C indicate allele name
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Genotype z The pair of alleles carried by an individual If there are n alternative alleles … … there will be
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This note was uploaded on 12/26/2011 for the course BIO 666 taught by Professor Staff during the Fall '06 term at University of Michigan.

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666.02 - Genes in Populations: Hardy Weinberg Equilibrium...

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