666.14 - IBS Methods for Affected Pairs Linkage...

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IBS Methods for Affected Pairs Linkage Biostatistics 666 Lecture 14
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Genetic Mapping “Compares the inheritance pattern of a trait with the inheritance pattern of chromosomal regions” Positional Cloning “Allows one to find where a gene is, without knowing what it is.”
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Where are the genes influencing a particular trait?
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Intuition for Linkage Analysis z Millions of variations could potentially be involved Costly to investigate each individually z Within families, variation is organized into a limited number of haplotypes Sample modest number of markers to determine whether each stretch of chromosome is shared
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Tracing Chromosomes A pedigree with several affected individuals
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Tracing Chromosomes Segregation pattern for chromosome carrying disease alleles
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Tracing Chromosomes 1 1 2 1 3 1 2 4 4 3 3 3 5 6 5 5 3 1 Segregation of a specific marker near the disease locus
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Tracing Chromosomes Multiple nearby markers can segregate in a manner that tracks disease! 1 2 1 2 1 2 3 4 3 4 3 4 1 4 1 4 1 4 1 3 1 3 1 3 1 3 1 4 1 4 2 4 2 4 2 4 1 3 1 3 1 3 1 4 1 4 1 4 1 2 1 2 1 2
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Today … z Linkage analysis with sibling pairs Identity-by-State (IBS) based method z Find markers that are near disease locus Near means recombination fraction θ < ½ z Minimalist approach …
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Reference for Today… z Power of IBS Methods for Linkage Analysis z Bishop DT and Williamson JA (1990) Am J Hum Genet 46: 254-265 z Recommended Reading
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Bishop and Williamson (1990) Opening Line "The availability of a large number of DNA markers has made possible mapping projects with the certainty that if:
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This note was uploaded on 12/26/2011 for the course BIO 666 taught by Professor Staff during the Fall '06 term at University of Michigan.

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666.14 - IBS Methods for Affected Pairs Linkage...

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