666.24 - The Elston-Stewart Algorithm Biostatistics 666 Lecture 24 Scheduling Important Dates Remaining Lectures April 5 7 14 Polio Symposium April

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The Elston-Stewart Algorithm Biostatistics 666 Lecture 24
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Scheduling – Important Dates z Remaining Lectures, April 5, 7, 14 z Polio Symposium, April 12 Rackham Auditorium, starts at 9:30 z Review Session, April 19 z Final Exam, April 27
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Last Lecture z The Lander Green Algorithm in practice z Computational refinements Speeding up transitions Reducing inheritance space z Non-parametric linkage analysis
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Today … z Elston-Stewart Algorithm Another approach to pedigree likelihoods Can handle very large pedigrees Limited to a few markers z Prelude to discussion of parametric linkage analysis
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So far … z Studying linkage to complex diseases Multiple environmental factors Multiple genetic susceptibility factors z Study affected sib pairs or small families z Find regions of excess similarity among affected individuals
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What about Mendelian traits? z Diseases caused by a single genetic defect z Typically, these are extremely rare Due to natural selection z We don’t need many families for mapping, but rather one or a few large families, where it is possible to track segregation of mutant alleles
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Typical Family for Mapping Mendelian Trait…
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The Problem z These families are typically too large for the Lander-Green algorithm z Impractical to enumerate all potential inheritance graphs… z Need an alternative formulation for the pedigree likelihood
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Elements of Pedigree Likelihoods z Prior Probabilities For founder genotypes z Segregation probabilities For offspring genotypes, given parents z Penetrances For individual phenotypes, given genotype
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This note was uploaded on 12/26/2011 for the course BIO 666 taught by Professor Staff during the Fall '06 term at University of Michigan.

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666.24 - The Elston-Stewart Algorithm Biostatistics 666 Lecture 24 Scheduling Important Dates Remaining Lectures April 5 7 14 Polio Symposium April

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