666.25 - Parametric Linkage Analysis Biostatistics 666...

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Parametric Linkage Analysis Biostatistics 666 Lecture 25
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Last Lecture z Elston Stewart Algorithm Can handle large pedigrees Proceeds one nuclear family at a time Limited to small numbers of markers z Calculates conditional probabilities for sections of the pedigree
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Today z Refresher on non-parametric analysis z Parametric linkage analysis Evaluates a specific trait model Disease allele frequencies Probability of disease for each genotype z Successfully mapped >1,000 rare disorders
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