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Unformatted text preview: a) What is the probability of this particular sample configuration? b) What is the probability of observing an equal or greater number of heterozygotes? c) What is the probability of observing a smaller number of heterozygotes? d) What is the chi-squared statistic for Hardy-Weinberg equilibrium? 3. Consider two loci in disequilibrium in a large population. Assume that the recombination fraction between the two loci is 0.01. In how many generations do you expect the disequilibrium coefficient D to be halved? 4. Consider the following set of haplotype frequencies: p AB = 0.3, p Ab = 0.2; p aB = 0.1; p ab = 0.4 a) Calculate D, D and 2 between the two markers. b) What is the probability that allele A will be present in a chromosome that carries allele b? c) What is the maximum possible value of r 2 for this marker pair?...
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This note was uploaded on 12/26/2011 for the course BIO 666 taught by Professor Staff during the Fall '06 term at University of Michigan.
- Fall '06