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Unformatted text preview: (1990) if 20 sibpairs who share genotype 3/3 are collected (this is the rare allele). 2. Now consider the MLS approach of Risch (1990) a) For the same polymorphism as in 1.c) above, calculate the MLS score using the EM algorithm to maximize the likelihood. b) Recalculate the LOD score assuming the 20 sibpairs share genotype 1/1. Can you explain the difference? c) Would your answers to a) or b) above change if you imposed the possible triangle constraint?...
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This note was uploaded on 12/26/2011 for the course BIO 666 taught by Professor Staff during the Fall '06 term at University of Michigan.
 Fall '06
 STAFF
 Genetics

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