Unformatted text preview: (1990) if 20 sib-pairs who share genotype 3/3 are collected (this is the rare allele). 2. Now consider the MLS approach of Risch (1990) a) For the same polymorphism as in 1.c) above, calculate the MLS score using the E-M algorithm to maximize the likelihood. b) Re-calculate the LOD score assuming the 20 sib-pairs share genotype 1/1. Can you explain the difference? c) Would your answers to a) or b) above change if you imposed the possible triangle constraint?...
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- Fall '06
- Genetics, IBS, LOD score, Affected Relative Pairs