{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

666.Prob06

# 666.Prob06 - (1990 if 20 sib-pairs who share genotype 3/3...

This preview shows page 1. Sign up to view the full content.

Biostatistics 666 Problem Set 6 Due Thursday March 23 Linkage Analysis of Affected Relative Pairs 1. Consider a polymorphism with three alleles, with frequencies p 1 = 0.50, p 2 = 0.30 and p 3 = 0.20. a) If a sample of affected sibling pairs were collected, what proportion of sib- pairs would you expect to share zero, one and two alleles IBS if the marker were not linked to any susceptibility genes? b) Repeat the previous analysis, but considering a sample of half-sibling pairs. c) Calculate the LOD score using the IBS test of Bishop and Williamson
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: (1990) if 20 sib-pairs who share genotype 3/3 are collected (this is the rare allele). 2. Now consider the MLS approach of Risch (1990) a) For the same polymorphism as in 1.c) above, calculate the MLS score using the E-M algorithm to maximize the likelihood. b) Re-calculate the LOD score assuming the 20 sib-pairs share genotype 1/1. Can you explain the difference? c) Would your answers to a) or b) above change if you imposed the possible triangle constraint?...
View Full Document

{[ snackBarMessage ]}

### What students are saying

• As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

Kiran Temple University Fox School of Business ‘17, Course Hero Intern

• I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

Dana University of Pennsylvania ‘17, Course Hero Intern

• The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

Jill Tulane University ‘16, Course Hero Intern