Unformatted text preview: consecutive loci and the second individual has genotype 2/2 at the same three loci. Assume that alleles 1 and 2 have frequency 0.50 at each locus. a) Let the recombination fraction between consecutive loci be θ = 0.0528. Based on the genotype data, what is the relative probability that the two individuals are siblings rather than half-siblings? b) Repeat the calculation above assuming the recombination fraction between consecutive loci is θ = 0.5. c) Comment on the difference between a) and b). What are the trade-offs that should be considered when deciding between the use of closely spaced markers versus markers that are far apart for relationship inference? d) How would you expect your results above to change if your model allowed for genotyping error?...
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This note was uploaded on 12/26/2011 for the course BIO 666 taught by Professor Staff during the Fall '06 term at University of Michigan.
- Fall '06