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Unformatted text preview: S pairs scoring function. The S pairs scoring fuction sums IBD sharing among all pairs affected individuals for each inheritance vector. e) Calculate the parametric LOD score for this family, assuming a disease model where the disease allele frequency is p D = 0.001 and the disease allele frequencies are f DD = 0.20, f Dd = 0.10 and f dd = 0.0. 2. Consider the pedigree and the inheritance graph below: E F A B C D G H i ii Calculate the probability of the observed genotypes conditional on the inheritance graph. In your calculations, denote the allele frequency of alleles 1, 2, 3 and 4 as p 1 , p 2 , p 3 and p 4 respectively. You can assume there is no genotyping error. 1 2 1 2 1 2 2 4 2 4 2 4 2 4...
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This note was uploaded on 12/26/2011 for the course BIO 666 taught by Professor Staff during the Fall '06 term at University of Michigan.
- Fall '06