lecture 3 - Defining Disease Lecture 3 Concepts of Disease:...

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1 Lecture 3 Concepts of Disease: Showing Cause Defining Disease o Disorder, interruption or cessation of the body’s normal state o Chronic o Acute o Infectious o Injury o Etiology – the science and study behind the cause of disease Association vs. Cause o Association – an identifiable relationship between exposure and disease o Spurious – false association o Non-causal – true association, not causal o Causal – true association, evidence for causation o Cause – exposure leads to disease o Changes in exposure lead to changes in disease o In epidemiology, we can’t prove cause , but we can infer cause using a set of postulates Theories of Disease Causation o Supernatural o Miasma o Theory of Contagion o Germ Theory o Classic Epidemiologic Theory o Multicausality and the Web of Causation Risk Factors for Disease o Frequency of disease varies by value of the factor (biological gradient) o Risk factor must precede disease onset o The observed association is not due to a source of error Basic Epi Question: How do we demonstrate that an exposure or a risk factor causes disease?
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2 Henle-Koch Postulates (~1890) 1. The agent is present in every case of
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This note was uploaded on 04/06/2008 for the course PUBLIC HEA 832:335 taught by Professor Schneider during the Spring '08 term at Rutgers.

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lecture 3 - Defining Disease Lecture 3 Concepts of Disease:...

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