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Lec1Post - CS 24 Problem Solving II (Data Structures) Diana...

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CS 24 – Problem Solving II (Data Structures) Diana Franklin
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Course Objectives Become a programmer More mature through practice Pointers, linked structures Recursion Data structures
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Course Objectives Manage Complexity – Complex systems change the world Analysis to make decisions on algorithms Choose proper data structures Learn object-oriented programming
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Code Complexity Google, Google, Google – how has it changed the world? Hundreds of programs execute for one query Millions of queries each day Web crawlers gathering data E-mails being read and sent Photos in Google+ and Picasa Everything is connected
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Big Data, Genomics, and Cancer 2010: Complete genomic characterization of a rare cancer tumor of one patient helped in clinical decision making and in identifying therapeutic approaches where no established treatment protocols existed 1st use of genomics to inform choice of cancer treatment options, stabilize cancer 34 researchers kept patient alive 6 months [1] Jones et al. (British Columbia Cancer Center) : Evolution of an adenocarcinoma in response to selection by targeted kinase inhibitors. Genome Biology 2010 11:R82. 5
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Big Data, Genomics, and Cancer Circos graph to compare genomes CNV: chromosomal copy number variation LOH: loss of heterozygosity T1 pre-treatment tumor cell T2 post-treatment tumor cell Δ degree of change between 2 cancers Large regions of Chromosomal loss 6
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Cancer Led to hypothesis of mechanism driving tumor and drugs to target it Clinic applied drug not approved for disease Shrank tumors by 22%, no new lesions Not cure, but stabilized rare cancer Could we economically scale up from 34 researchers/1 patient in 3 months to a million patients per year? 7
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This note was uploaded on 12/27/2011 for the course CMPSC 24 taught by Professor Agrawal during the Fall '09 term at UCSB.

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Lec1Post - CS 24 Problem Solving II (Data Structures) Diana...

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