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lec16-14 - heart rate E.4 Autonomic control of Autorhythmic...

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KIN 205: Chapter 14, Cardiovascular Physiology: Figure 14-16a 1. Enhancement of the long-lasting Ca 2+ current (increased Ca 2+ influx) via modulation of the ionic conductance through the cAMP second messenger pathway. 2. Decrease of the threshold for the pacemaker current which induces more frequent firing of pacemaker action potential. This results in an increase in
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Unformatted text preview: heart rate. E.4 Autonomic control of Autorhythmic cells: Sympathetic system: Effects on the autorhythmic cells (SA node): Norepinephrine is release by post-ganglionic neurons and exerts its effects via binding to β 1-adrenergic receptors. The activation of β 1-adrenergic receptors results in modulation of several ionic currents, mainly:...
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