lec18-14 - KIN 205: Chapter 12, Smooth Muscle: Signal...

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Unformatted text preview: KIN 205: Chapter 12, Smooth Muscle: Signal ligands ECF Depolarization of stretch Membrane receptors Membrane channels Modulatory pathways Increased IP3 Increased Ca2+ entry Store-operated Ca2+ channels Decreased intracellular Ca2+ stores IP3-R Alter MLCK or myosin phosphatase Alter actinassociated proteins Intracellular fluid Sarcoplasmic Ca2+ release Cell response Figure 12-30 ...
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