1.28.10.bb - Office Hours start today at 2:30-4:30pm Jon...

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Office Hours start today at 2:30-4:30pm Jon Paczkowski Weill 367 Review on Monday Feb 2, WRN245 Adam & Patrice
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Absorption spectra of the common nucleotides Measurement for NA concentrations Ch8 :8 (9)
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High energy bonds α β γ p.10
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Nucleoside 5'-triphosphates are carriers of energy ATP is central to energy metabolism GTP drives protein synthesis CTP drives lipid synthesis UTP drives carbohydrate metabolism Bases serve as recognition units Cyclic nucleotides are signal molecules and regulators of cellular metabolism and reproduction Functions of Nucleotides
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5’ 3’ DNA and RNA chains have polarity Follow the sugar-P backbone to determine polarity
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Shorthand notations for oligonucleotide chains 3’ 5’ P 3’ 5’ G P 3’ 5’ C P 3’ 5’ A P 3’ 5’ T P OH T P G C A T T 5’ 3’ or  sim ply Study guide p.107, #1, 2, 4, 7- 9 Chapter 8 : 3, 8 , 10 5’ TGCAT 5 C sugar
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Chemistry of nucleic acids The double helix Movie:2902 The double helix 10-01 Lehninger 3rd P = yellow, C= black, H= white, N=blue, O= red Chapter 8 : 6, 9, 12 (6, 13) Study guide, p.108, #5, 10, 13-14
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DNA and RNA have many similarities, but also differences: 1. DNA is usually double-stranded, and therefore rigid RNA is single-stranded and flexible 2. The nucleotides of DNA are ATGC, RNA are AUGC. 3. RNA has 2’OH, they are susceptible to alkali hydrolysis
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1.28.10.bb - Office Hours start today at 2:30-4:30pm Jon...

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