Hemostasis - Sequence of local events following device...

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12/27/11 1 Sequence of local events following device implantation Injury Injection, implantation, blood vessel damage Acute inflammation Polymorphonuclear leukocytes Chronic inflammation Monocytes and Macrophages Granulation tissue Fibroblasts and new blood capillaries Foreign body reaction Macrophages and FBGCs at the material-tissue interface Fibrosis Fibrous capsule
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12/27/11 2 Hemostasis: Vasoconstriction Figure 16-12: Platelet plug formation
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12/27/11 3 Hemostasis The process of blood clotting and then the subsequent dissolution of the clot, following repair of the injured tissue. Composed of 4 major events that occur in a set order following the loss of vascular integrity: 1. vascular constriction . This limits the flow of blood to the area of injury. 2. platelets become activated by thrombin and aggregate at the site of injury, forming a temporary, loose platelet plug . The protein fibrinogen is primarily responsible for stimulating platelet clumping. Platelets clump by binding to collagen that becomes exposed following rupture of the endothelial lining of vessels.
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12/27/11 4 Hemostasis (continued) Upon activation, platelets release ADP and TXA 2 (which activate additional platelets), serotonin, phospholipids, lipoproteins , and other proteins important for the coagulation cascade. In addition to induced secretion, activated platelets change their shape to accommodate the formation of the plug. 3. To insure stability of the initially loose platelet plug, a fibrin mesh (also called the clot ) forms and entraps the plug. 4. Finally, the clot must be dissolved in order for normal blood flow to resume following tissue repair. The dissolution of the clot occurs through the action of plasmin .
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12/27/11 5 Overview of Hemostasis:
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12/27/11 6 Platelet Activation
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12/27/11 7
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12/27/11 8 SEM of Platelets
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12/27/11 9 Platelet Activation Platelets bind to matrix and spread to cover the damaged surface; aggregation to form temporary plug; Initiates the wound healing process through the
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This note was uploaded on 12/27/2011 for the course STEP 1 taught by Professor Dr.aslam during the Fall '11 term at Montgomery College.

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Hemostasis - Sequence of local events following device...

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