Non-invasive_Breast_Cancer

Non-invasive_Breast_Cancer - Noninvasive Breast Cancer...

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Noninvasive Breast Cancer Overview Vic V. Vernenkar, D.O. St. Barnabas Hospital Department of Surgery 2003
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Noninvasive Breast Cancer DCIS and LCIS DCIS proliferation of epithelial cells confined to mammary ducts. LCIS confined to the lobules with no invasion of BM. No risk of metastases.
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DCIS DCIS increased threefold with mammography 10-20 per 100,000. 20-44 % of all new screen detected neoplasms. Age 47-63 years. Frequency of family history of breast cancer among 1 st degree relatives same as invasive 10-35%.
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Pathology of DCIS From ductal epithelium. Heterogeneous group of lesions with variable histologic characteristics. Malignant cells proliferate and obstruct the duct. Five subtypes: comedo, solid, cribiform, micropapillary, and papillary.
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DCIS
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Pathology of DCIS Cribiform, comedo, and micropapillary are the most common. Van Nuys classification to identify prognostic features nuclear grade plus comedo. 1- non-high-grade DCIS without comedo. 2- non-high-grade DCIS with comedo. 3- high grade DCIS with or without comedo.
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Pathology of DCIS Group I had 3.8 recurrence after BCS. Group II had 11.1% recurrence after BCS. Group III had 26.5% recurrence after BCS. 8 year disease free survival rates were 93% for group I, 84% group II, and 61% in group III.
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Multifocality is defined as two or more foci separated by 5mm in the same quadrant. Multicentricity is defined as DCIS having a separate focus outside the index quadrant. It varies from 18-60%. Approximately 96% of recurrences after
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This note was uploaded on 12/27/2011 for the course STEP 1 taught by Professor Dr.aslam during the Fall '11 term at Montgomery College.

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Non-invasive_Breast_Cancer - Noninvasive Breast Cancer...

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