Pathology of the Pancreas

Pathology of the Pancreas - Pathology of the Pancreas...

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Unformatted text preview: Pathology of the Pancreas Alyssa Krasinskas, MD krasinskasam@upmc.edu January 6, 2003 Normal Peripancreatic fat Pancreatic parenchyma Normal Pancreas- Gross & Micro Congenital Anomalies Agenesis Pancreatic Divisum Annular pancreas Heterotopic pancreas Cysts True Congenital Acquired (pseudocysts) Neoplastic Congenital Anomalies - Heterotopic Pancreas (in stomach) Congenital Anomalies - Heterotopic Pancreas (in stomach) Congenital Anomalies - Cysts Simple Cyst Ductal derived Microscopic to 3-5 cm Lined by flat cuboidal duct-type epithelium Filled with fluid Usually solitary and asymptomatic Cysts associated with other diseases Polycystic kidney disease Cysts in kidney, liver, pancreas Von Hippel-Lindau disease Cysts in pancreas, liver, kidney CNS angiomas Congenital Anomalies - Pancreatic Cyst - Gross & Micro Modern Pathology 15:154-158 (2002) Acute Pancreatitis Autodigestion and inflammation of the pancreas Most common causes: Alcoholism Obstruction Gallstones Tumor, scar, congenital abnormality Possible mechanisms: Duct obstruction Acinar cell injury Defective intracellular transport Acute Pancreatitis - Pathology Edema (microvascular leakage) Fat necrosis and saponification (release of lipolytic enzymes) Interstitial hemorrhage (destruction of blood vessel walls) Parenchymal necrosis (release of proteolytic enzymes) Acute inflammation Mild cases Edema, fat necrosis and saponification Severe cases (necrotizing pancreatitis) Necrosis of acinar cells, ducts, islets Fat necrosis (within and outside of abdomen) Necrosis of blood vessels - hemorrhage Acute Pancreatitis - Pathology Edema (microvascular leakage) Fat necrosis and saponification (release of lipolytic enzymes) Interstitial hemorrhage (destruction of blood vessel walls) Parenchymal necrosis (release of proteolytic enzymes) Acute inflammation Acute Pancreatitis - Pathology Mild cases Edema, fat necrosis and saponification Severe cases (necrotizing pancreatitis) Necrosis of acinar cells, ducts, islets...
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Pathology of the Pancreas - Pathology of the Pancreas...

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