Primary_hemostasis-1

Primary_hemostasis-1 - PrimaryHemostasis...

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    Primary Hemostasis Monday, October 27, 2003 Reading- Hemostasis    (pp 12-13)
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    Introduction to Hemostasis The hemostatic system helps to ensure that blood is confined to, and flows freely within the  circulatory system .   Hemorrhage, intravascular thrombosis, and embolism  are common clinical manifestations of many  diseases.    •The normal hemostatic system limits blood loss by precisely regulated interactions between  components of the  vessel wall, circulating blood platelets, and plasma proteins   •When  disease or trauma  damage large vessels,  bleeding  may occur, despite a normal  hemostatic  system.   Hemorrhage  is also caused by an  inherited or acquired disorder  of the hemostatic machinery  itself.
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    The Arrest of Bleeding •Mechanisms underlying the arrest of bleeding are 2-fold:   -- vasoconstriction  (narrowing of blood vessels) to help prevent further blood loss;   -- formation of a hemostatic plug  (a "thrombus or clot") derived from platelets and  fibrin strands, in which RBC's/WBC's are trapped.
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    Definition of Hemostasis Hemostasis  is defined as the process  that maintains the flowing blood  in a fluid  state  and confined  to the circulatory system .   •The hemostatic mechanism is  not  a  single biological pathway , but the product of  the  complex interactions  of a number  of distinct  systems :   --vascular system; --blood platelets; --blood coagulation system; --fibrinolytic system; --inhibitors of the above systems. 
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    Definition of Hemostasis (cont’d) Accurate diagnosis and treatment  of patients with either bleeding or thrombosis  requires some knowledge of the  pathophysiology of hemostasis .     Divided into primary and secondary components  and is initiated when  trauma/surgery, or diseases disrupt the  vascular endothelial lining  and blood is  exposed to  subendothelial connective tissue
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Primary_hemostasis-1 - PrimaryHemostasis...

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