IMG_0001_NEW_0031 - pair of electransf electrons in a-tr...

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I How does understanding the reuctivity of ucids und bases relate to understanding reuctionsT In general: the key to understanding organic reactions is understanding where available electrons are and where they want to go (or with which atoms they want to form bonds) - think of reactions as interactions between electron rich and electron deficient atoms. 1. electron rich atoms - want to share electrons by donating them to the formation of a new bond. NUCLEOPHILE 2. electron poor atoms - want to accept electrons through the formation of a new bond. ELECTROPIIILE Identifying nucleophiles and electrophiles Nucleophile a) must have a !o+e
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Unformatted text preview: pair of electransf electrons in a-tr bong-that are iess tightly held and therefore available to react b) may or may not be-ogsaliyels.ahargsd c) the more accessible the lone pair is, the better the nucleophile d) in general, when comparing nucleophiles with the same nucleophilic atom :-serelrs.ric-= recall: the higher pKa of conjugate acid the stronger the base e.g two different oxygen nucleophiles /\f vs OO {bn /7 o A Zr l^PAhlr hze p'- ,u^"hryrlale e) when nucleophilic atoms are not the same you must also consider atomic size e.s. Ta f Pba4c'P- 3 -7 p* rucwb. fl^4 ,arlw/'lz dhoJor bao ,Mtr nuc/en/ulz...
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This note was uploaded on 12/27/2011 for the course CHEM 281 taught by Professor Williams during the Fall '11 term at Simon Fraser.

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